Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

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Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro.In addition to their known anticoagulants activity this potential inhibition cashel tail bag could have an additional therapeutic effect on patients with COVID-19 disease.In this study we examined the binding of the Apixaban, Betrixaban and Rivaroxaban to the SARS-CoV-2 Mpro with the use of turbo air m3f72-3-n the MicroScale Thermophoresis technique.

Our results indicate that the experimentally measured binding affinity is weak and the therapeutic effect due to the SARS-CoV-2 Mpro inhibition is rather negligible.